

917), but also with body weight, surface area, and functional residual capacity. The volume of the anatomic dead space correlated closely with height (Vd (ml) 7.585 x Ht (cm)2.363 x 10-4.

However, differences in the exact way of measuring this space result in clinically significant different results and, therefore, debate remains about the true value of this measured parameter.Ĭopyright © 2023, StatPearls Publishing LLC. The respiratory anatomic dead space has been measured by the single breath nitrogen washout method of Fowler in 73 normal subjects ranging from 4 to 42 years of age. Indeed, it may serve as a prognostic factor in patients with acute repository distress syndrome (ARDS) who require ventilation. This phenomenon has clinical significance because, both in healthy and impaired lungs, properly calculating and accounting for this non-physiological space is important for the proper respiratory care of ventilated patients. This is therefore termed anatomical dead space as it serves no respiratory function. High pulmonary dead space is associated with increased mortality in ARDS patients.

Anatomic dead space is an important phenomenon in respiratory physiology whereby, owing to the fact that upper airways do not function as locations for gas exchange, and because of the tidal nature of ventilation, there is always a fraction of the inspired air that does not perform a physiologic function of exchanging carbon dioxide for oxygen.
